Inhibit Plasmin 3 EPU/mg pro Aprotinin from Bovine Lung and Inhibit
Aprotinin is a competitive serine protease inhibitor that inhibits
trypsin, chymotrypsin, kallikrein and plasmin. Aprotinin forms
stable complexes with and blocks the active sites of enzymes.
Binding is reversible with most aprotinin-protease complexes and
dissociating at pH >10 or <3. Effective concentration is
equimolar with protease.
Recombinant Animal Components Free
Recombinant aprotinin is expressed in E. Coli, and purified by HPLC. It contains no animal-derived components.
This is a recombinant form of bovine lung aprotinin, which is
traditionally isolated from bovine lung by methods involving
fractional precipitation, gel filtration, and ion exchange
Unit Definition:One trypsin inhibitor unit (EPU) will decrease the activity of 2
trypsin units by 50% where one trypsin unit will hydrolyze 1.0 μmol
of N-benzoyl-L-arginineethyl ether(BAEE) per sec at pH 7.6 at 25
°C.A conversion factor for Aprotinin is: 1 EPU= 1 USP Aprotinin
Unit = 1800 KIU.
Recombinant aprotinin should be stored under -20°C or below in
sealed container.It is stable within 24 months.